HYBRID EVENT: You can participate in person at Madrid, Spain or Virtually from your home or work.

2nd Edition of Global Conference on

Physical Medicine and Rehabilitation

September 09-11, 2024 | Madrid, Spain

GCPR 2023

Selma Denis Squassoni

Speaker at Physical Medicine and Rehabilitation 2023 - Selma Denis Squassoni
FMABC University Center, Brazil
Title : Autologous stem cell infusion in COPD patients: Impact on quality of life and physical performance


Chronic obstructive pulmonary disease (COPD) is a serious disease that affects millions of people around the world, however, there is still no well-established curative treatment. Quality of life and the six-minute walk test (6MWT) are used to evaluate the response of COPD patients to treatment. Stem cell therapy is a promising therapeutic alternative with great potential in these patients.

Objectives: to evaluate the impact of autologous stem cell infusion on quality of life and physical performance in patients with COPD.

Interventions: Twenty patients with advanced COPD were randomized into four groups: Control (no stem cell therapy); BMMC (bone marrow mononuclear cells collected by aspiration of the iliac crest; MSC-AT (mesenchymal stem cells derived from adipose tissue; and Coinfusion (BMMC and MCS-AT infused at the same time). The parameters of the 6MWT and quality of life questionnaire were evaluated over 12 months after treatment.

Results: Treated groups showed improvement of the quality of life over the baseline score in relation to the Control group: Coinfusion (47.62%); MCS-AT (34.22%); BMMC (10.39%). The 6MWT results showed no difference in distances, but the Borg scale scores and oxygen saturation (SatO2) levels did not decrease.

Conclusions: Stem cell treatments, especially autologous MCS-AT and the combination of MCS-AT with autologous BMMC tended to modify the quality of life positively, without deteriorating physical performance after 12 months of follow-up compared to the results following conventional treatment (control). Stem cells may provide a new therapeutic approach with broad potential to be investigated in patients with advanced COPD.


Physiotherapist graduated in 1993, Master's degree in Health Sciences Quality of Life from Centro Universitário FmABC 2004 and PhD in Health Sciences from Centro Universitário FmABC 2018, supervisor of the postgraduate internship at Centro Universitário FmABC (FMABC), volunteer member of the research ethics committee of the Centro Universitário FmABC. She has experience in Physiotherapy and Occupational Therapy, with emphasis on Respiratory Physiotherapy, working mainly on the following topics: COPD, pulmonary rehabilitation, walking test, quality of life and smokers.