Histology is a discipline of biology that examines the microscopic anatomy of biological tissues. It is sometimes known as microscopic anatomy or microanatomy. Histology is the microscopic counterpart to gross anatomy, which examines bigger structures that are not visible without the use of a microscope. Although one may separate microscopic anatomy into organology, the study of organs, histology, the study of tissues, and cytology, the study of cells, modern use places all of these disciplines under the field of histology The skeleton is made up of several types of specialised connective tissue. Bone and cartilage, like all other connective tissues, consist of cells and extracellular matrix. It is the ground component of the matrix which is largely responsible for the noticeable distinctions between bone and cartilage. The mineralization of bone's ground substance makes it rigid and strong, but fragile. Cartilage is hard and incompressible, but more flexible and resilient than bone, due to its non-mineralized ground component, which is more like very firm Jelly.