The role of metabolic and endocrine rehabilitation is gaining attention as hormonal imbalances and metabolic disorders significantly impact physical function and recovery. Conditions such as diabetes, thyroid dysfunction, and adrenal insufficiency can affect muscle strength, energy levels, and healing capacity. Rehabilitation strategies focus on optimizing metabolic health through tailored exercise programs, nutritional interventions, and medication management. Resistance training and aerobic exercise play a crucial role in improving insulin sensitivity and bone density, while dietary modifications support endocrine balance. Additionally, emerging therapies, including pharmacological agents that target metabolic pathways, are enhancing rehabilitation outcomes. A multidisciplinary approach integrating endocrinology, nutrition, and physical medicine helps individuals achieve better functional independence and long-term well-being.