Chronic pain remains a significant barrier to mobility and quality of life, necessitating advancements in pain management & interventional pain therapies. Pharmacological solutions, including multimodal analgesia, are being refined to minimize opioid dependence, while regenerative treatments such as platelet-rich plasma and stem cell therapy show promise in tissue healing. Interventional techniques like nerve blocks, radiofrequency ablation, and spinal cord stimulation provide targeted relief for persistent pain conditions. Complementary approaches, including cognitive behavioral therapy, acupuncture, and biofeedback, are also gaining traction in comprehensive pain management. A multidisciplinary approach that combines medical, psychological, and rehabilitative strategies ensures that pain treatment is both effective and sustainable, enhancing patient functionality and long-term well-being.