Improving quality of life for individuals with serious illnesses is a primary goal of palliative care and rehabilitation, which focuses on symptom management, mobility preservation, and emotional well-being. Physical and occupational therapy interventions help maintain independence, while pain management techniques enhance comfort. Assistive technologies and adaptive equipment further support functional capabilities. Emotional and psychological support, including counseling and mindfulness-based therapies, play a vital role in helping patients cope with progressive conditions. A collaborative approach between rehabilitation specialists, palliative care teams, and caregivers ensures that individuals receive compassionate, holistic care, promoting dignity and comfort throughout their journey.