Managing functional decline and symptom burden is essential in rehabilitation in chronic and autoimmune diseases, where progressive conditions such as multiple sclerosis, rheumatoid arthritis, and lupus impact daily activities. Rehabilitation strategies focus on improving mobility, reducing fatigue, and enhancing muscle strength through individualized exercise regimens. Pain management techniques, including hydrotherapy and neuromuscular stimulation, provide relief from musculoskeletal discomfort. Cognitive training and occupational therapy support independence, while lifestyle modifications and psychological counseling help patients adapt to long-term challenges. A multidisciplinary approach ensures that individuals maintain the highest possible level of function, improving overall quality of life.